This speech should be heartfelt and will detail how beautiful his Bride is and perhaps how they met. So things a groom should mention:
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The Groom is expected to thank his family and his Bride's family for all their support during the wedding (though it is a little vulgar to mention money outright!)
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You should mention your gratitude at the support and love you have received throughout your life from your parents and for any gifts you and your new wife have received